research and deliberations


I have been doing lots of research and thinking about aromatase inhibitors (AI) since my appointment with Dr. Mehta on Tuesday. The reach of this blog has grown beyond my circle of friends, so I’m hopeful that what I have learned may be of interest to others.

AI’s inhibit estrogen manufactured in the ovaries, liver, and in the fatty tissue under the skin (dangerous dioxins). I learned that there is bad estrogen as well as good estrogen, which is important for heart health and other bio-functions. There are numerous side effects of the drug form of AI’s, and they affect both the good estrogen as well as the bad. Because drugs are treated as a foreign substance in the body,  they must be detoxified through the liver. This places additional strain on it which can possibly lead to liver cancer or liver disease.  Because they are a foreign substance, the body’s immune system interprets them as invaders and mounts a defense against them, eventually rendering the drug ineffective. Drugs compromise the health of the immune system.

Being overweight and obesity are both linked to breast cancer; aromatase enzymes reside in fat cells. It is important to be weight conscious and embrace some form of regular exercise appropriate for you. Insulin levels should be kept under control by avoiding processed and chemicalized foods.

I have been pursuing links which touch on natural forms of AI’s and have discovered that the most effective one is Chrysin, a flavonoid from the passion-flower. It has been found to be equal in potency to AI drugs. Research has shown that Chrysin will block the suppression of NK (natural killer) cells which are an important part of the immune system. The inclusion of Piperine (black pepper) enhances the bioavailability of Chrysin in the body.

Scientists have discovered that the most potent natural compound is Indole 3 Carbinol (I3C) — it is a wonder compound! Along with Chrysin, it includes:                                                                                                                                                   Phytoestrogens found in green vegetables, fruits, chick peas and beans                                                                                                                                                                                                                                                                                                                  Quercetin found in garlic, kale, brussel sprouts, cabbage, apples, and onions                                                                                                                                                                                                                                                                                                    Resveratrol found in the skins of red grapes and black/red berries

Another great flavonoid is Apigenin which is found in parsley, celery and chamomile.

The general recommendation is that alcohol should be avoided as it feeds the aromatase enzymes; however red wine in moderation does have therapeutic benefits due to resveratrol.

I plan to continue reading and researching as well as look for quality, plant-based supplements as an effective alternative to a drug form of an aromatase inhibitor.

NOTE:  Nothing in this post represents medical advice. I have compiled this information solely, after extensive research as a seeker of an alternative to aromatase inhibitors.

. . . and so it is

5 thoughts on “research and deliberations

  1. Your research background and caring interest to share this with others is greatly appreciated. Well written and always full of information.. thanks for your posts Deb!!! ~Hillary

  2. Billie says:

    Thank you so much Deb. So Interesting, and so helpful

  3. Dolores Esposito says:

    Your sharing of valuable information is very much appreciated and I trust you will make the decision that’s best for you. You are always in my prayers.

  4. Loretta Shatt says:

    Thanks again for your wonderful blogs and the great photos.
    your sharing is much appreciated.
    As I remember from some research I did a few years back, when natural substances are used to produce a new drug, as they most often are, the drug company must tweak the compound to be able to patent the drug. It is this tweaking that makes the body treat the drug as a foreign substance. Wouldn’t it be nice if the drug companies put our health first?

  5. I’m so glad you are doing your research and making decisions that are best for you. Thank you for sharing what you’re learning.

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